In this article

What the Panel Measures

The SiPhox Allergy Panel measures IgE antibodies to food and environmental allergens and reports Total IgE to help contextualize overall allergy load. Results for each allergen are grouped into clear categories such as negative/uncertain, low, moderate, high, and very high so you can see where sensitization may be clinically meaningful.

Coverage includes 295 allergens across 165 sources, spanning:

  • Foods: dairy, eggs, nuts, seafood, fruits, vegetables, grains, spices
  • Environmental triggers: pollen (trees, grasses, weeds), dust mites, molds, pets
  • Other exposures: insect venom, latex, and known cross-reactive proteins

The Testing Process

  1. Purchase – Order your Allergy Panel through SiPhox Health.
  2. At-home sample – Use the EasyDraw arm collector for a simple, comfortable blood collection.
  3. Processing – The lab analyzes your IgE antibody responses across the allergen panel.
  4. Results timeline – Reports are typically available within 5–7 business days.

What You Receive

  • Per-allergen IgE values with category bands from negative/uncertain to very high
  • Total IgE to help gauge overall sensitization
  • Grouped summaries to help spot patterns across allergen families
  • Notes on cross-reactivity to inform next steps and conversations with your clinician

About Our Testing

Our testing is performed in a CLIA- and CAP-accredited laboratory, and the IgE assays we use have been analytically validated, including comparison to standard venous blood draws. While no test is perfect, we are confident in the accuracy and reliability of the results based on these validations.

Why It Matters

Understanding your IgE profile can help identify likely triggers, support more personalized diet and lifestyle decisions, and provide useful information to discuss with your allergist or healthcare provider. Whether your results are positive or negative, they’re a meaningful piece of the puzzle and a valuable step toward understanding what’s behind your symptoms.

Understanding Different Types of Allergy Testing

Not all allergy-related tests measure the same thing, so results from different test types should not be compared as though they are equivalent. See the AAAAI overview of allergy testing.

IgE testing

IgE blood testing looks for antibodies associated with allergic sensitization. These results can help identify substances that may trigger symptoms such as hives, itching, wheezing, nasal congestion, or other immediate-type allergic reactions. See NIAID’s overview of diagnosing food allergy and the AAAAI explanation of allergy testing.

Patch testing

Patch testing is used to evaluate delayed contact reactions, such as contact dermatitis caused by substances like fragrances, metals, adhesives, or preservatives. It does not measure IgE antibodies and is designed for a different type of immune response. See the AAD page on patch testing.

IgG testing

IgG food testing is different from IgE testing and is often interpreted as a marker of exposure rather than a true allergy. Because of this, IgG results are not interchangeable with IgE allergy testing. See the AAAAI article on IgG food testing.

Got Mostly Negative Results? That’s Often a Good Thing.

If your panel came back largely negative, you might be wondering if something went wrong. It didn’t. Here’s what’s actually going on.

A positive IgE test doesn’t automatically mean you have an allergy — and a negative result doesn’t mean your symptoms aren’t real.

IgE testing measures sensitization, which is your immune system’s potential to react to something. But sensitization is not the same as a clinical allergy. Many people are sensitized without ever having noticeable symptoms, and many people have real symptoms (like digestive issues, headaches, or skin reactions) that are driven by other mechanisms — not IgE at all. Reactions like food intolerances, IgG-mediated responses, or non-immune sensitivities won’t show up on an IgE panel, and that’s expected.

Our test is specifically designed to reduce false positives — which means fewer incorrect “hits.”

The ALEX platform uses CCD blockers and molecular allergen components, which is a more precise approach than older extract-based tests. Traditional tests can flag things that look like allergies but aren’t — a phenomenon called CCD-driven false positives that can affect up to 30% of results on older platforms. ALEX is built to screen those out. So if you’ve had a previous allergy test that showed more positives, some of those may have been inaccurate to begin with.

Previous tests may have picked up cross-reactivity as a “positive.”

It’s common for older panels to flag a reaction to, say, a fruit — when the real culprit is actually pollen cross-reacting at the extract level. The ALEX platform analyzes allergens at the molecular level, which lets it separate true sensitizations from cross-reactive noise. This can make results look different from what you’ve seen before, even when both tests are technically working correctly.

Timing matters too.

IgE levels can shift depending on your recent exposure history. If you’ve been avoiding a food or haven’t been in contact with an environmental trigger in a while, your IgE levels for that allergen may be lower at the time of testing. This is one reason why blood IgE and skin prick tests don’t always agree with each other either.

Bottom line: A negative or low-positive ALEX result is not a malfunction — it’s often a more specific and reliable answer. If your results don’t match your symptoms, that’s a conversation worth having with your doctor, who can factor in your full history.

Why Results May Differ

IgE results can vary across laboratories and over time. Different labs may assess different allergen components within the same category, such as specific proteins within nuts, grasses, or dust mites. Labs may also use different methodologies, allergen panels, and detection thresholds, which can lead to results that do not appear identical.

IgE levels also reflect current sensitization, which means they may change depending on exposure patterns and immune response. As a result, a prior allergy test from another lab may not match exactly, even when both tests are technically accurate. For that reason, allergy results are best interpreted in the context of your symptoms, history, and any prior testing rather than viewed as a perfect one-to-one comparison.