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What is DHEA-S?

DHEA (dehydroepiandrosterone) is a hormone produced primarily by the adrenal glands of the kidneys, but also by the ovaries and testes in smaller amounts, and converted into DHEA-S (dehydroepiandrosterone sulfate) by the adrenal glands and liver. DHEA-S serves as a precursor for testosterone and estrogen, the primary sex hormones for males and females.

Why is DHEA-S important?

DHEA-S levels provide a glimpse into sexual and reproductive health given its connection with testosterone and estrogen. DHEA-S is currently included in the SiPhox Health male base panel as well as the female Hormone+ panel. It serves as a good indicator of overall adrenal function and can potentially point toward adrenal tumors or hyperplasia (enlargement).

How can I better understand my results?

Generally, it is advisable to fall within the higher end of the normal range. To assist in interpreting results, Mount Sinai established normal ranges of DHEA-S broken down by age and sex:

Male:

  • Age 18-19: 108-441 ug/dL
  • Age 20-29: 280-640 ug/dL
  • Age 30-39: 120-520 ug/dL
  • Age 40-49: 95-530 ug/dL
  • Age 50-59: 70-310 ug/dL
  • Age 60-69: 42-290 ug/dL
  • Age 69+: 28-175 ug/dL

Female:

  • Age 18-19: 145-395 ug/dL
  • Age 20-29: 65-380 ug/dL
  • Age 30-39: 45-270 ug/dL
  • Age 40-49: 32-240 ug/dL
  • Age 50-59: 26-200 ug/dL
  • Age 60-69: 13-130 ug/dL
  • Age 69+: 17-90 ug/dL

According to MedlinePlus, abnormally high DHEA-S may be caused by adrenal hyperplasia, adrenal tumors, or PCOS in females, while low levels may indicate Addison’s disease or hypopituitarism. It is important to consult with your physician if you are concerned with your results.

How can I maintain optimal DHEA-S levels?

If you have low DHEA-S, here are some lifestyle modifications you can try:

Lifestyle Changes: If you want to increase your DHEA-S levels, studies have shown that practicing MSBR (mindfulness-based stress reduction) such as through yoga or meditation may help. DHEA-S levels can also be raised through regular exercise, especially with high-intensity interval training (HIIT).

Supplementation: If you have low DHEA-S levels, supplementing with ashwagandha may help.

If you have elevated DHEA-S levels, you can try:

Lifestyle Changes: If you wish to lower your DHEA-S levels, practicing intermittent fasting may help.

Supplementation: Consuming fish oil and vitamin E supplements may help in decreasing elevated DHEA-S levels.

Where can I learn more?

DISCLAIMER: IF YOU ARE CONCERNED WITH ANY OF YOUR RESULTS, PLEASE CONSULT WITH YOUR PHYSICIAN.