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What is LDL-C?

LDL-C stands for Low-Density Lipoprotein Cholesterol. It is often referred to as “bad” cholesterol because high levels of LDL-C can lead to the accumulation of cholesterol in the arteries, contributing to atherosclerosis (the buildup of plaque in the arteries) and increasing the risk of heart disease and stroke. LDL-C carries cholesterol from the liver to the cells of the body, but when there is an excess, it can deposit cholesterol in the artery walls, leading to the formation of plaque. Lowering LDL-C levels through lifestyle changes or medication is a key part of managing and reducing the risk of cardiovascular disease.

Note: While VLDL, IDL, LDL, or Lp(a) particles in themselves are not “bad”, high levels of these lipoproteins can build up and block arteries (pro-atherogenic). These lipoproteins, however, are healthy in moderation, and very low levels can have negative implications, too.

Why is LDL-C important?

Despite advancements in understanding atherosclerosis risks, LDL-C continues to hold value in cardiovascular risk assessment and is included as a biomarker in the SiPhox Health Foundation panel. This persistence is due in part to the extensive body of guidelines and recommendations that still prioritize LDL-C levels. Measuring LDL-P poses challenges due to difficulties in achieving precise measurements. To bridge this gap, SiPhox also includes ApoB in its assessments, offering a broader view of atherogenic particles, encompassing LDL-P. This dual measurement strategy ensures that both healthcare providers and patients have a comprehensive understanding of atherosclerotic cardiovascular disease risk, facilitating more informed health decisions (Cole, 2023).

How can I better understand my LDL-C levels?

To better interpret your results, Johns Hopkins Medicine has released ranges for LDL-C:

  • Optimal: 40-100 mg/dL
  • Elevated: 100-130 mg/dL
  • Borderline High: 130-160 mg/dL
  • High: 160-190 mg/dL
  • Very High: > 190 mg/dL

How can I maintain optimal LDL-C levels?

If your LDL-C is elevated, here are some changes you can try:

Dietary Changes: Avoiding foods with saturated fat, trans fat, and cholesterol and increasing soluble fiber intake can help to lower elevated LDL-C levels.

Lifestyle Changes: Maintaining a healthy weight, regularly exercising, quitting cigarettes, and limiting alcohol intake can help to regulate increased LDL-C levels.

Supplementation: Supplementing with whey protein can also help to decrease LDL-C levels.

Where can I learn more?

DISCLAIMER: IF YOU ARE CONCERNED WITH ANY OF YOUR RESULTS, PLEASE CONSULT WITH YOUR PHYSICIAN.